Infrared thermographic imaging is a useful tool for diagnosing complex regional pain syndrome. CRPS can be associated with abnormal skin temperature regulation, described by patients as a "hot" or "cold" feeling with skin discoloration in the affected area.

Infrared thermal imaging after "cold stress" to the body can easily detect these temperature abnormalities. Thermography is most sensitive when the CRPS is unilateral. Although there are no "normal" skin temperature values, research is currently underway at various centers in Europe.